Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 24127964
Gene Name BCL2
Condition Endometriosis
Association Associated
Population size 30
Population details 30 women in reproductive age with a clinical or sonographic suspicion of endometrioma
Age 25 – 39 yrs
Sex Female
Associated genes Bcl-2, Bax and Mcl-1
Other associated phenotypes Severe endometriosis
Apoptosis through regulation of Bcl-2, Bax and Mcl-1 expressions in endometriotic cyst lesions and the endometrium of women with moderate to severe endometriosis.

J Obstet Gynaecol. 2013 Oct;33(7):725-8. doi: 10.3109/01443615.2013.824416.

Korkmaz, D| Bastu, E| Dural, O| Yasa, C| Yavuz, E| Buyru, F

Department of Obstetrics and Gynaecology, Medicana Bahcelievler Hospital.

The aim of the study was to evaluate apoptosis through regulation of Bcl-2, Bax and Mcl-1 proteins by comparing their expressions in endometriotic cyst lesions and the endometrium of the patients with moderate to severe endometriosis. This is a cross-sectional study of 30 women in reproductive age with a clinical or sonographic suspicion of endometrioma, who underwent laparoscopy. Bcl-2 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly reduced in the cystic endometriotic lesions (p < 0.0001). There was a significant difference in Bcl-2 expression between cystic endometriotic stromal cells and endometrial stromal cells (p < 0.0001). Bax expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the endometrium (p < 0.0001). There was a significant difference in Bax expression between cystic endometriotic stromal cells and endometrial stromal cells (p = 0.03). Mcl-1 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the cystic endometriotic lesions (p = 0.003). Apoptosis may play a role in the pathophysiology of endometriosis by potentially contributing to the survival of regurgitating endometrial cells in the peritoneal cavity.

Mesh Terms: Adult| *Apoptosis| Cross-Sectional Studies| Cysts/metabolism| Endometriosis/*metabolism| Female| Humans| Myeloid Cell Leukemia Sequence 1 Protein/*metabolism| bcl-2-Associated X Protein/*metabolism|DA 2014/05/21 06:00